methyl 2-(4-(difluoromethoxy)phenyl)-2-methylpropanoate - Names and Identifiers
methyl 2-(4-(difluoromethoxy)phenyl)-2-methylpropanoate - Introduction
methyl 2-(4-(difluoromethoxy)phenyl)-2-methylpropanoate is an organic compound with the chemical formula C12H13F2O3.
Nature:
1. Appearance: colorless liquid
2. Melting Point: No data
3. Boiling Point: No data
4. Density: No data
5. Solubility: Soluble in organic solvents, such as ether and dichloromethane
Use:
methyl 2-(4-(difluoromethoxy)phenyl)-2-methylpropanoate is an important organic synthesis intermediate, widely used in the preparation of drugs, pesticides and dyes and other compounds. It can be used as a substitute for ethyl formate and has good stability and solubility, thus facilitating its application in synthesis.
Method:
methyl 2-(4-(difluoromethoxy)phenyl)-2-methylpropanoate can be synthesized by the following steps:
1.2-methyl acetone and p-fluorocresol are reacted under alkaline conditions to obtain 2-(4-fluoromethoxy) acetophenone.
2. The above product is reacted with difluoromethanol under alkaline conditions to obtain 2-(4-(difluoromethoxy) phenyl)-2-methylacetone.
3. Finally, the above product is reacted with methanol to obtain the target product methyl 2-(4-(difluoromethoxy)phenyl)-2-methylpropanoate.
Safety Information:
Note the following safety precautions when using and handling methyl 2-(4-(difluoromethoxy)phenyl)-2-methylpropanoate:
1. Avoid contact with skin, eyes and respiratory tract. Wear protective gloves, goggles and respiratory protection when using.
2. Use in a well-ventilated place to avoid inhaling gas or steam.
3. Avoid contact with oxidants and strong acids to avoid dangerous reactions.
4. Should be stored away from fire and high temperature, avoid direct sunlight.
5. If accidental leakage, it should be removed quickly and corresponding protective measures should be taken.
Last Update：2024-04-09 21:00:56